FCGR2C

Across TCGA pan-cancer cohorts, FCGR2C RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FCGR2C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FCGR2C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FCGR2C is over-expressed in tumor, although a few such as UCEC and LUSC show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where FCGR2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FCGR2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.470	<.001	12	view →
THCA	All	IV	+1.142	.017	5	view →
KIRP	Male	All	+1.021	<.001	3	view →
HNSC	Female	All	+0.508	.012	3	view →
LUAD	All	All	+0.531	.003	2	view →
UCEC	All	All	−0.453	.002	2	view →
CHOL	All	All	+0.856	.015	1	view →
LUSC	All	All	−0.343	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FCGR2C–KIRC

Open the KIRC breakdown →