FCGR1A

Across TCGA pan-cancer cohorts, FCGR1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FCGR1A data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FCGR1A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FCGR1A expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where FCGR1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.667	0.953	.001	53	view →
PDAC	DFS	Quartile	All	0.634	0.946	.002	31	view →
UCEC	DFS	Tertile	All	0.787	0.973	.024	4	view →
GBM	OS	Quartile	All	0.293	0.622	.028	2	view →
HNSC	OS	Tertile	IV	0.869	0.617	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FCGR1A–CCRCC (OS)

Open the CCRCC breakdown →