FCGR1A

Across TCGA pan-cancer cohorts, FCGR1A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FCGR1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FCGR1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FCGR1A is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where FCGR1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FCGR1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.425	<.001	12	view →
KIRP	Male	All	+1.739	<.001	11	view →
COAD	Female	II,III,IV	+0.891	<.001	11	view →
LUAD	Female	All	−0.929	<.001	10	view →
HNSC	All	All	+0.536	.001	10	view →
THCA	All	IV	+1.155	<.001	9	view →
STAD	Female	All	+1.762	<.001	8	view →
BLCA	All	All	+0.653	.007	7	view →
BRCA	All	All	+1.289	<.001	6	view →
LUSC	Male	II,III,IV	−1.457	<.001	5	view →
READ	Male	All	+1.856	.041	2	view →
LIHC	Female	II,III,IV	+0.447	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FCGR1A–KIRC

Open the KIRC breakdown →