FCF1

Across TCGA pan-cancer cohorts, FCF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FCF1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FCF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FCF1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, HNSC, and LUAD are the cancer types where FCF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.665	0.320	.019	6	view →
HNSC	DFS	Tertile	IV	0.552	0.825	.015	6	view →
LUAD	OS	Median	II,III,IV	0.360	0.917	.007	4	view →
CCRCC	DFS	Tertile	All	0.349	0.821	.004	4	view →
LSCC	DFS	Quartile	II,III,IV	0.927	0.495	.009	4	view →
UCEC	DFS	Quartile	All	0.912	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FCF1–GBM (OS)

Open the GBM breakdown →