FCF1

Across TCGA pan-cancer cohorts, FCF1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FCF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FCF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FCF1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where FCF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FCF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.149	<.001	12	view →
THCA	Male	III,IV	−0.799	<.001	10	view →
BLCA	All	III,IV	+0.656	<.001	10	view →
LIHC	Male	All	+0.615	<.001	7	view →
KIRP	All	II,III,IV	+0.515	.005	6	view →
LUSC	All	All	+0.481	<.001	6	view →
CHOL	Male	All	+1.511	<.001	5	view →
KICH	All	All	−0.575	<.001	5	view →
STAD	All	All	+0.376	.011	4	view →
COAD	Male	All	+0.224	.034	4	view →
LUAD	All	All	+0.198	.001	4	view →
ESCA	All	All	+0.668	.013	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FCF1–HNSC

Open the HNSC breakdown →