FBXW9

Across TCGA cell cohorts, FBXW9 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible FBXW9-associated genes across cancer lineages are SLC22A8, GPR101, and OR1L6. Each is linked with FBXW9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW9-to-partner and partner-to-FBXW9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A8 grouped by FBXW9-low versus FBXW9-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW9→partner) and Y-score (partner→FBXW9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC22A8 →	+0.016	+3.628	.002	.002	3	2
OVARY	GPR101 →	+0.019	+3.990	<.001	.003	3	2
OVARY	OR1L6 →	+0.012	+4.222	<.001	.006	3	2
OVARY	OR1J2 →	+0.057	+3.938	.002	.005	3	2
BLOOD_Myeloma	OR1A1 →	+0.413	+4.807	.001	.006	3	1
BLOOD_Leukemia	DIRAS2 →	+0.055	+2.814	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

SLC22A8 by FBXW9 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →