FBXW8

Across TCGA pan-cancer cohorts, FBXW8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FBXW8 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FBXW8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FBXW8 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where FBXW8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.428	1.000	.002	16	view →
GBM	DFS	Median	All	0.298	0.435	.020	14	view →
CCRCC	DFS	Tertile	II,III,IV	0.402	0.801	.014	10	view →
LSCC	DFS	Quartile	III,IV	0.488	1.000	.020	10	view →
PDAC	OS	Median	III,IV	0.824	0.661	.045	2	view →
HNSC	DFS	Median	IV	0.502	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FBXW8–LUAD (OS)

Open the LUAD breakdown →