FBXW8

Across TCGA patient cohorts, FBXW8 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,997 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FBXW8-associated proteins across cancer lineages are SART3, SNRPD3, and TRRAP. Each is linked with FBXW8 in more than 7 cancer types. Because this analysis shows association rather than direction, both FBXW8-to-partner and partner-to-FBXW8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXW8 versus SART3 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW8→partner) and Y-score (partner→FBXW8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SART3 →	+0.250	+0.504	<.001	<.001	3	8
OV	SNRPD3 →	+0.349	+0.862	<.001	<.001	3	7
HNSC	TRRAP →	+0.276	+0.706	<.001	.001	3	6
GBM	BRD7 →	+0.260	+0.309	<.001	<.001	3	6
LSCC	INTS3 →	+0.209	+0.428	<.001	<.001	3	6
GBM	PRCC →	+0.374	+0.420	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,997 associations by consensus.

FBXW8 vs SART3 — LSCC

Explore this scatter interactively →