FBXW8

Across TCGA patient cohorts, FBXW8 protein abundance is significantly associated with the RNA expression of many other genes, with 7,679 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FBXW8-associated genes across cancer lineages are CCDC8, ARMH4, and RPL26P26. Each is linked with FBXW8 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBXW8-to-partner and partner-to-FBXW8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXW8 versus CCDC8 in CCRCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW8→partner) and Y-score (partner→FBXW8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CCDC8 →	+1.502	+0.312	.001	<.001	3	5
LSCC	ARMH4 →	+0.718	+0.242	<.001	.004	3	4
HNSC	RPL26P26 →	+0.838	+0.537	<.001	<.001	3	4
HNSC	FN1 →	+1.257	+0.501	.003	<.001	3	4
BRCA	CNN1 →	+0.961	+0.343	<.001	<.001	3	4
GBM	POSTN →	+2.315	+0.313	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,679 associations by consensus.

FBXW8 vs CCDC8 — CCRCC

Explore this scatter interactively →