FBXW8

Across TCGA patient cohorts, FBXW8 mutation is significantly associated with the RNA expression of many other genes, with 1,294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW8-associated genes across cancer lineages are RNU4-26P, FAM30C, and RPS12P15. Each is linked with FBXW8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW8-to-partner and partner-to-FBXW8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-26P grouped by FBXW8-low versus FBXW8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW8→partner) and Y-score (partner→FBXW8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	2
CESC	FAM30C →	+0.083	+6.569	<.001	.001	3	2
SKCM	RPS12P15 →	+0.073	+2.591	<.001	.004	3	2
UCEC	ABHD3 →	+0.819	+3.180	<.001	<.001	3	2
UCEC	EDA →	-0.801	-3.676	<.001	.001	3	2
UCEC	LRR1 →	+0.608	+3.345	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,294 associations by consensus.

RNU4-26P by FBXW8 expression — HNSC

Explore this box plot interactively →