FBXW7

Across TCGA patient cohorts, FBXW7 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,467 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FBXW7-associated proteins across cancer lineages are RAB30, SEPTIN6, and CNRIP1. Each is linked with FBXW7 in more than 6 cancer types. Because this analysis shows association rather than direction, both FBXW7-to-partner and partner-to-FBXW7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXW7 versus RAB30 in LSCC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW7→partner) and Y-score (partner→FBXW7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAB30 →	+0.473	+0.432	<.001	<.001	3	6
GBM	SEPTIN6 →	+0.369	+0.454	.003	<.001	3	6
GBM	CNRIP1 →	+0.567	+0.405	<.001	<.001	3	6
LUAD	MRPL47 →	-0.431	-0.383	<.001	<.001	2	7
LSCC	MRPS27 →	-0.361	-0.353	<.001	.001	3	6
OV	MRPS5 →	-0.391	-0.625	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,467 associations by consensus.

FBXW7 vs RAB30 — LSCC

Explore this scatter interactively →