FBXW7

Across TCGA patient cohorts, FBXW7 mutation is significantly associated with the RNA expression of many other genes, with 6,693 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW7-associated genes across cancer lineages are ATP5F1B, SMPD1, and C1QBP. Each is linked with FBXW7 in more than 7 cancer types. Because this analysis shows association rather than direction, both FBXW7-to-partner and partner-to-FBXW7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1B grouped by FBXW7-low versus FBXW7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW7→partner) and Y-score (partner→FBXW7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5F1B →	+0.467	+1.279	<.001	<.001	3	8
LUSC	SMPD1 →	-0.504	-2.458	<.001	.001	3	7
STAD	C1QBP →	+0.638	+3.484	.001	.002	3	7
READ	LINC00659 →	+1.128	+2.533	<.001	.005	3	7
UCS	CD99 →	-0.754	-3.070	.002	.005	3	6
STAD	FASTKD1 →	+0.600	+3.372	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,693 associations by consensus.

ATP5F1B by FBXW7 expression — UCEC

Explore this box plot interactively →