FBXW7

Across TCGA cell cohorts, FBXW7 mutation is significantly associated with the RNA expression of many other genes, with 1,644 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXW7-associated genes across cancer lineages are CCT8L2, RAD51AP2, and IQCH. Each is linked with FBXW7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW7-to-partner and partner-to-FBXW7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT8L2 grouped by FBXW7-low versus FBXW7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW7→partner) and Y-score (partner→FBXW7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCT8L2 →	+0.029	+4.371	<.001	.005	3	2
OVARY	RAD51AP2 →	+0.088	+3.963	<.001	.004	3	2
LARGE_INTESTINE	IQCH →	+0.371	+3.584	.004	<.001	3	2
LARGE_INTESTINE	DHX58 →	+1.278	+1.969	<.001	<.001	3	2
BLOOD_Leukemia	FAM149A →	+1.113	+3.502	<.001	.002	3	2
LARGE_INTESTINE	PRDM4 →	+0.542	+2.451	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,644 associations by consensus.

CCT8L2 by FBXW7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →