FBXW7-AS1

Across TCGA pan-cancer cohorts, FBXW7-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated FBXW7-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher FBXW7-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXW7-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and READ show a favorable association.

LGG, MESO, and LAML are the cancer types where FBXW7-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.658	0.807	<.001	45	view →
MESO	OS	Tertile	III,IV	0.178	0.670	.002	30	view →
LAML	DFS	Median	All	0.554	0.276	.007	30	view →
READ	DFS	Tertile	II,III,IV	0.847	0.371	.002	26	view →
ESCA	OS	Median	III,IV	0.583	0.309	.008	18	view →
STAD	OS	Median	II,III,IV	0.571	0.236	.011	18	view →
LUAD	DFS	Quartile	IV	0.203	0.663	.028	18	view →
ACC	DFS	Median	IV	0.133	0.508	.001	18	view →
CESC	DFS	Quartile	II,III,IV	0.616	0.813	.004	16	view →
UCS	OS	Tertile	IV	0.844	0.251	.019	12	view →
LIHC	OS	Tertile	II,III,IV	0.888	0.555	.032	9	view →
HNSC	OS	Median	IV	0.651	0.383	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

FBXW7-AS1–LGG (DFS)

Open the LGG breakdown →