FBXW7-AS1

Across TCGA pan-cancer cohorts, FBXW7-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FBXW7-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where FBXW7-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXW7-AS1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, LUSC, and CHOL are the cancer types where FBXW7-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW7-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.285	.001	6	view →
LUSC	Female	III,IV	+0.464	.002	3	view →
CHOL	All	All	+0.220	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

FBXW7-AS1–BRCA

Open the BRCA breakdown →