FBXW5

Across TCGA pan-cancer cohorts, FBXW5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FBXW5’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where FBXW5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FBXW5 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where FBXW5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	−0.558	<.001	9	view →
LUAD	All	III,IV	−0.287	<.001	9	view →
HNSC	Male	III,IV	−0.677	<.001	8	view →
CCRCC	All	All	+0.113	.001	4	view →
COAD	Male	II,III,IV	−0.770	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FBXW5–LSCC

Open the LSCC breakdown →