FBXW5

Across TCGA pan-cancer cohorts, FBXW5 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated FBXW5 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FBXW5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXW5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and DLBC show a favorable association.

ACC, UCEC, and UVM are the cancer types where FBXW5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.228	0.665	<.001	129	view →
UCEC	DFS	Tertile	III,IV	0.814	0.390	<.001	60	view →
UVM	DFS	Quartile	All	0.319	0.826	.001	54	view →
LGG	DFS	Median	All	0.674	0.795	<.001	32	view →
DLBC	OS	Median	All	1.000	0.792	.003	29	view →
UCS	OS	Tertile	IV	0.189	1.000	.038	24	view →
LUAD	OS	Median	All	0.764	0.855	.001	22	view →
MESO	OS	Median	III,IV	0.336	0.683	.016	21	view →
LAML	DFS	Median	All	0.415	0.678	.005	18	view →
PRAD	DFS	Median	All	0.845	0.923	.003	18	view →
SARC	OS	Quartile	All	0.886	0.619	.003	16	view →
CHOL	OS	Quartile	II,III,IV	0.948	0.175	.024	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

FBXW5–ACC (DFS)

Open the ACC breakdown →