FBXW5

Across TCGA patient cohorts, FBXW5 protein abundance is significantly associated with the RNA expression of many other genes, with 9,459 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FBXW5-associated genes across cancer lineages are STMN1, FAM72B, and AKR1C3. Each is linked with FBXW5 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXW5-to-partner and partner-to-FBXW5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXW5 versus STMN1 in LSCC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW5→partner) and Y-score (partner→FBXW5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STMN1 →	-0.966	-0.242	<.001	<.001	3	4
LSCC	FAM72B →	-0.695	-0.311	<.001	<.001	3	4
LUAD	AKR1C3 →	+1.807	+0.331	<.001	<.001	3	4
BRCA	FANCG →	-0.330	-0.253	.002	.003	3	4
UCEC	ADH1C →	+1.527	+0.234	.001	.002	3	4
LSCC	VRK1 →	-0.616	-0.209	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,459 associations by consensus.

FBXW5 vs STMN1 — LSCC

Explore this scatter interactively →