FBXW5

Across TCGA patient cohorts, FBXW5 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW5-associated genes across cancer lineages are MSH6, ATM, and IGFBP2. Each is linked with FBXW5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW5-to-partner and partner-to-FBXW5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by FBXW5-low versus FBXW5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW5→partner) and Y-score (partner→FBXW5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MSH6 →	-0.390	-3.144	.043	.019	3	2
UCEC	ATM →	-0.407	-1.807	.029	.027	3	2
COAD	IGFBP2 →	+0.812	+3.195	.018	.010	3	1
COAD	AMPK_alpha →	-0.204	-3.127	.021	.019	3	1
UCEC	ERK2 →	+0.177	+2.584	.025	.010	3	1
UCEC	JNK2 →	+0.249	+3.348	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MSH6 by FBXW5 expression — COAD

Explore this box plot interactively →