FBXW5

Across TCGA cell cohorts, FBXW5 mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXW5-associated genes across cancer lineages are PTCHD3, IZUMO1R, and MAGEB5. Each is linked with FBXW5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW5-to-partner and partner-to-FBXW5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTCHD3 grouped by FBXW5-low versus FBXW5-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW5→partner) and Y-score (partner→FBXW5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PTCHD3 →	+0.023	+3.510	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.056	+4.321	<.001	<.001	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
URINARY_TRACT	NEUROG3 →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	GOLGA6L1 →	+0.020	+5.087	<.001	.004	3	1
LARGE_INTESTINE	RSPH6A →	+0.086	+2.688	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

PTCHD3 by FBXW5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →