FBXW4P1

Across TCGA pan-cancer cohorts, FBXW4P1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FBXW4P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FBXW4P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXW4P1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

HNSC, STAD, and THCA are the cancer types where FBXW4P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW4P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.497	<.001	8	view →
STAD	All	II,III,IV	+0.401	<.001	8	view →
THCA	All	II,III,IV	+0.304	<.001	8	view →
KIRC	Male	All	−0.150	<.001	8	view →
LUAD	Female	III,IV	+0.753	<.001	7	view →
LUSC	Male	II,III,IV	+0.576	<.001	7	view →
LIHC	All	II,III,IV	+0.219	<.001	7	view →
COAD	Female	All	+0.382	<.001	6	view →
BRCA	All	III,IV	−0.354	<.001	6	view →
CHOL	Male	All	+0.773	<.001	4	view →
READ	Male	All	+0.233	.018	3	view →
KIRP	Female	All	−0.213	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FBXW4P1–HNSC

Open the HNSC breakdown →