FBXW4

Across TCGA pan-cancer cohorts, FBXW4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FBXW4 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FBXW4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FBXW4 expression acts as an unfavorable survival marker.

LUAD, BLCA, and ACC are the cancer types where FBXW4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.223	0.677	.006	15	view →
BLCA	DFS	Median	IV	0.090	0.469	.009	12	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FBXW4–LUAD (OS)

Open the LUAD breakdown →