FBXW4

Across TCGA patient cohorts, FBXW4 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW4-associated genes across cancer lineages are Neutrophils, CD8+ Tcm, and HSC. Each is linked with FBXW4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW4-to-partner and partner-to-FBXW4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophils grouped by FBXW4-low versus FBXW4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW4→partner) and Y-score (partner→FBXW4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Neutrophils →	+0.021	+1.681	<.001	.049	3	2
UCEC	CD8+ Tcm →	+0.032	+2.350	.001	.031	3	1
UCEC	HSC →	+0.186	+3.008	<.001	.019	3	1
UCEC	Class-switched memory B-cells →	-0.060	-3.459	.035	.005	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Neutrophils by FBXW4 expression — UCEC

Explore this box plot interactively →