FBXW12

Across TCGA pan-cancer cohorts, FBXW12 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBXW12 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FBXW12 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXW12 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LGG, and BRCA are the cancer types where FBXW12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.621	.017	10	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
BRCA	DFS	Median	II,III,IV	0.321	0.889	.006	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBXW12–UCEC (DFS)

Open the UCEC breakdown →