FBXW10

Across TCGA patient cohorts, FBXW10 mutation is significantly associated with the RNA expression of many other genes, with 3,563 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW10-associated genes across cancer lineages are NCAPH2, ATP6V1D, and PSMD9. Each is linked with FBXW10 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXW10-to-partner and partner-to-FBXW10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPH2 grouped by FBXW10-low versus FBXW10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW10→partner) and Y-score (partner→FBXW10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH2 →	+0.651	+2.536	<.001	<.001	3	4
UCEC	ATP6V1D →	+0.403	+2.321	<.001	.005	3	3
SKCM	PSMD9 →	+0.279	+2.839	.003	.002	3	3
SKCM	MRPS15 →	+0.320	+2.260	.002	.005	3	3
SKCM	MASTL →	+0.558	+2.128	.003	.009	3	3
SKCM	PSMB2 →	+0.334	+1.970	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,563 associations by consensus.

NCAPH2 by FBXW10 expression — UCEC

Explore this box plot interactively →