FBXW10

Across TCGA pan-cancer cohorts, FBXW10 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FBXW10 data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FBXW10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXW10 expression acts as an unfavorable survival marker, although some lineages such as UCS and OV show a favorable association.

KIRC, ACC, and UCS are the cancer types where FBXW10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.527	0.708	<.001	117	view →
ACC	DFS	Tertile	All	0.231	0.654	<.001	99	view →
UCS	DFS	Median	III,IV	0.404	0.150	.009	48	view →
KICH	OS	Quartile	All	0.654	1.000	<.001	43	view →
OV	DFS	Median	III,IV	0.412	0.334	.011	38	view →
COAD	DFS	Median	All	0.399	0.685	.013	28	view →
SARC	OS	Median	All	0.636	0.333	<.001	24	view →
LGG	OS	Tertile	All	0.537	0.383	.006	22	view →
UVM	OS	Tertile	III,IV	0.517	0.879	.012	21	view →
HNSC	OS	Median	III,IV	0.731	0.593	.009	21	view →
KIRP	OS	Quartile	All	0.867	1.000	<.001	14	view →
LIHC	OS	Quartile	II,III,IV	0.417	0.748	.015	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FBXW10–KIRC (DFS)

Open the KIRC breakdown →