FBXW10

Across TCGA cell cohorts, FBXW10 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,907 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible FBXW10-associated GO terms across cancer lineages are Negative regulation of canonical NF-kappaB signal transduction, Cellular response to thyroid hormone stimulus, and Response to L-phenylalanine derivative. Each is linked with FBXW10 in more than 8 cancer types. Because this analysis shows association rather than direction, both FBXW10-to-partner and partner-to-FBXW10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of canonical NF-kappaB signal transduction grouped by FBXW10-low versus FBXW10-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW10→partner) and Y-score (partner→FBXW10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of canonical NF-kappaB signal transduction →	+0.052	+0.286	<.001	.001	3	9
LUNG_NSCLC_LUSC	Cellular response to thyroid hormone stimulus →	+0.191	+0.687	<.001	.009	3	8
URINARY_TRACT	Response to L-phenylalanine derivative →	+0.145	+0.557	<.001	<.001	3	8
LIVER	DNA repair-dependent chromatin remodeling →	+0.062	+1.135	.008	.005	3	8
KIDNEY	Cellular response to jasmonic acid stimulus →	+1.066	+0.650	.002	.007	2	9
KIDNEY	Negative regulation of transforming growth factor beta production →	+0.282	+0.763	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,907 associations by consensus.

Negative regulation of canonical NF-kappaB signal transduction by FBXW10 expression — BREAST

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