FBXW10

Across TCGA cell cohorts, FBXW10 mutation is significantly associated with the RNA expression of many other genes, with 291 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXW10-associated genes across cancer lineages are CACNG1, FAM181A, and CYP4Z1. Each is linked with FBXW10 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW10-to-partner and partner-to-FBXW10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNG1 grouped by FBXW10-low versus FBXW10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW10→partner) and Y-score (partner→FBXW10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CACNG1 →	+0.072	+3.881	.002	.006	3	1
BLOOD_Leukemia	FAM181A →	+0.017	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CYP4Z1 →	+0.063	+3.944	<.001	.006	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TCP11X2 →	+0.099	+4.060	.002	.003	3	1
LARGE_INTESTINE	ANKRD54 →	+0.471	+2.451	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 291 associations by consensus.

CACNG1 by FBXW10 expression — BLOOD_Leukemia

Explore this box plot interactively →