FBXO9

Across TCGA patient cohorts, FBXO9 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO9-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, EGFR_pY1173, and eIF4G. Each is linked with FBXO9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO9-to-partner and partner-to-FBXO9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by FBXO9-low versus FBXO9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO9→partner) and Y-score (partner→FBXO9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.394	+1.678	.043	.023	3	2
UCEC	EGFR_pY1173 →	+0.097	+3.169	.001	.018	3	1
UCEC	eIF4G →	+0.320	+2.000	.007	.030	3	1
UCEC	FOXO3a_pS318_S321 →	-0.118	-2.087	.013	.005	3	1
UCEC	INPP4B →	-0.298	-2.222	.016	.009	3	1
UCEC	Ku80 →	+0.211	+1.335	.020	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Acetyl-a-Tubulin-Lys40 by FBXO9 expression — UCEC

Explore this box plot interactively →