FBXO9

Across TCGA pan-cancer cohorts, FBXO9 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FBXO9 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher FBXO9 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FBXO9 expression acts as an unfavorable survival marker, although some lineages such as PAAD and KIRC show a favorable association.

PAAD, ACC, and KIRC are the cancer types where FBXO9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Median	All	0.502	0.276	<.001	63	view →
ACC	DFS	Median	All	0.270	0.635	<.001	62	view →
KIRC	OS	Median	All	0.712	0.557	<.001	56	view →
MESO	OS	Tertile	All	0.558	0.289	.001	43	view →
KIRP	DFS	Median	IV	0.039	0.524	.002	35	view →
OV	OS	Median	IV	0.761	0.479	.005	32	view →
HNSC	DFS	Median	IV	0.715	0.571	.002	30	view →
LUSC	OS	Median	All	0.932	0.703	<.001	25	view →
LGG	OS	Quartile	All	0.749	0.874	.006	25	view →
LUAD	OS	Median	All	0.743	0.633	.005	24	view →
UCS	OS	Tertile	IV	1.000	0.304	.033	12	view →
ESCA	OS	Quartile	II,III,IV	0.390	0.666	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FBXO9–PAAD (OS)

Open the PAAD breakdown →