FBXO8

Across TCGA patient cohorts, FBXO8 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO8-associated genes across cancer lineages are ERK2, INPP4B, and MSH2. Each is linked with FBXO8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO8-to-partner and partner-to-FBXO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FBXO8-low versus FBXO8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO8→partner) and Y-score (partner→FBXO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.221	+3.459	.003	.005	3	1
UCEC	INPP4B →	-0.340	-2.700	.007	.005	3	1
UCEC	MSH2 →	-0.222	-3.295	.014	.009	3	1
UCEC	Rab25 →	-0.327	-1.584	.011	.036	3	1
UCEC	Tuberin →	+0.317	+1.584	.002	.036	3	1
UCEC	VHL →	-1.098	-2.700	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ERK2 by FBXO8 expression — UCEC

Explore this box plot interactively →