FBXO8

Across TCGA cell cohorts, FBXO8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,718 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FBXO8-associated GO terms across cancer lineages are Ribosome biogenesis, Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Vesicle targeting, to, from or within Golgi. Each is linked with FBXO8 in more than 10 cancer types. Because this analysis shows association rather than direction, both FBXO8-to-partner and partner-to-FBXO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosome biogenesis grouped by FBXO8-low versus FBXO8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO8→partner) and Y-score (partner→FBXO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Ribosome biogenesis →	-0.094	-0.994	<.001	<.001	3	11
OESOPHAGUS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.118	-0.742	.006	<.001	3	11
LARGE_INTESTINE	Vesicle targeting, to, from or within Golgi →	+0.078	+0.531	.002	.001	3	10
PANCREAS	UDP biosynthetic process →	-0.121	-0.681	.001	.004	3	10
BLOOD_Leukemia	Golgi organization →	+0.045	+0.515	<.001	<.001	3	10
BLOOD_Leukemia	Pyrimidine nucleoside diphosphate biosynthetic process →	-0.053	-0.356	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,718 associations by consensus.

Ribosome biogenesis by FBXO8 expression — URINARY_TRACT

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