FBXO8

Across TCGA cell cohorts, FBXO8 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO8-associated genes across cancer lineages are OR10AC1, SCYGR10, and C6orf118. Each is linked with FBXO8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO8-to-partner and partner-to-FBXO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AC1 grouped by FBXO8-low versus FBXO8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO8→partner) and Y-score (partner→FBXO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10AC1 →	+0.027	+4.273	<.001	.006	3	1
SKIN	SCYGR10 →	+0.194	+4.684	<.001	.002	3	1
LARGE_INTESTINE	C6orf118 →	+0.118	+2.793	<.001	.002	3	1
LARGE_INTESTINE	TBR1 →	+0.040	+3.748	<.001	.001	3	1
LARGE_INTESTINE	CISD2 →	+0.692	+3.125	.002	.008	3	1
LARGE_INTESTINE	CD300H →	+0.024	+3.415	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR10AC1 by FBXO8 expression — SKIN

Explore this box plot interactively →