FBXO6

Across TCGA patient cohorts, FBXO6 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO6-associated genes across cancer lineages are CMP, aDC, and CD8+ naive T-cells. Each is linked with FBXO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO6-to-partner and partner-to-FBXO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP grouped by FBXO6-low versus FBXO6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO6→partner) and Y-score (partner→FBXO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CMP →	+0.037	+3.413	<.001	.034	3	1
UCEC	aDC →	+0.065	+2.177	.049	.035	3	1
UCEC	CD8+ naive T-cells →	+0.032	+3.186	.008	.010	3	1
UCEC	CD8+ Tcm →	+0.029	+2.935	.001	.001	3	1
UCEC	lymphatic Endothelial cells →	-0.022	-2.281	.041	.035	3	1
UCEC	Macrophages →	+0.015	+2.176	.019	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CMP by FBXO6 expression — STAD

Explore this box plot interactively →