Across TCGA patient cohorts, FBXO48 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO48-associated genes across cancer lineages are eEF2, GAPDH, and Ku80. Each is linked with FBXO48 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO48-to-partner and partner-to-FBXO48 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO48→partner) and Y-score (partner→FBXO48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.437	+2.584	.008	.011	3	1
UCEC	GAPDH →	+0.661	+3.321	.008	.010	3	1
UCEC	Ku80 →	+0.300	+3.713	.006	<.001	3	1
UCEC	MEK1 →	+0.579	+2.584	<.001	.011	3	1
UCEC	MSH2 →	-0.341	-3.312	.001	.010	3	1
UCEC	Notch1 →	+0.174	+3.013	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

FBXO48 survival (RNA) · tumor vs normal (RNA) · all FBXO48 data types