Across TCGA pan-cancer cohorts, FBXO48 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FBXO48’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FBXO48 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXO48 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
HNSC, KIRC, and THCA are the cancer types where FBXO48 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO48 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.