FBXO46

Across TCGA patient cohorts, FBXO46 protein abundance is significantly associated with the RNA expression of many other genes, with 800 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FBXO46-associated genes across cancer lineages are ANKRD22, SNX14, and CCL22. Each is linked with FBXO46 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO46-to-partner and partner-to-FBXO46 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXO46 versus ANKRD22 in UCEC, with a Pearson correlation of -0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO46→partner) and Y-score (partner→FBXO46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANKRD22 →	-2.010	-0.910	<.001	.007	3	2
HNSC	SNX14 →	-0.633	-0.503	<.001	.006	3	2
UCEC	CCL22 →	-1.309	-0.911	<.001	<.001	3	1
UCEC	SLC17A5 →	+0.645	+0.795	.003	.004	3	1
UCEC	IRAK2 →	-1.805	-0.952	.001	.005	3	1
UCEC	STRA6 →	-1.194	-0.593	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 800 associations by consensus.

FBXO46 vs ANKRD22 — UCEC

Explore this scatter interactively →