FBXO46

Across TCGA pan-cancer cohorts, FBXO46 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FBXO46 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher FBXO46 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO46 expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

MESO, LIHC, and ACC are the cancer types where FBXO46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.267	0.503	<.001	108	view →
LIHC	DFS	Median	All	0.370	0.496	<.001	96	view →
ACC	OS	Median	All	0.349	0.815	<.001	88	view →
UCEC	DFS	Median	All	0.797	0.875	.008	54	view →
KIRP	DFS	Median	All	0.355	0.745	<.001	46	view →
LGG	DFS	Median	All	0.658	0.820	<.001	32	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	32	view →
COAD	OS	Quartile	III,IV	0.555	0.879	.011	32	view →
HNSC	DFS	Median	All	0.751	0.641	.001	30	view →
KIRC	DFS	Quartile	All	0.477	0.709	.002	28	view →
LUAD	DFS	Quartile	All	0.716	0.851	.001	26	view →
BLCA	OS	Quartile	IV	0.385	0.175	.004	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FBXO46–MESO (DFS)

Open the MESO breakdown →