FBXO46

Across TCGA patient cohorts, FBXO46 mutation is significantly associated with the RNA expression of many other genes, with 2,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO46-associated genes across cancer lineages are RNU6-1067P, RPL17-C18orf32, and CCT4P1. Each is linked with FBXO46 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO46-to-partner and partner-to-FBXO46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1067P grouped by FBXO46-low versus FBXO46-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO46→partner) and Y-score (partner→FBXO46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1067P →	+0.340	+3.984	<.001	.009	3	2
CESC	RPL17-C18orf32 →	+0.075	+3.500	.004	.007	3	2
SKCM	CCT4P1 →	+0.060	+3.609	<.001	.002	3	2
UCEC	ZNF256 →	+0.438	+2.201	.003	<.001	3	2
UCEC	CXCL13 →	+1.408	+2.201	<.001	<.001	3	2
UCEC	ZMYND19 →	+0.477	+2.617	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,037 associations by consensus.

RNU6-1067P by FBXO46 expression — CESC

Explore this box plot interactively →