FBXO46

Across TCGA patient cohorts, FBXO46 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO46-associated genes across cancer lineages are eIF4G, STAT3_pY705, and Di-Ras3. Each is linked with FBXO46 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO46-to-partner and partner-to-FBXO46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by FBXO46-low versus FBXO46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO46→partner) and Y-score (partner→FBXO46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.256	+2.999	.031	.035	3	2
UCEC	STAT3_pY705 →	-0.261	-2.087	.009	.005	3	2
UCEC	Di-Ras3 →	-0.201	-3.687	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.130	-3.673	<.001	.001	3	1
UCEC	eEF2 →	+0.307	+2.321	.025	.033	3	1
UCEC	EGFR_pY1068 →	-0.216	-2.459	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4G by FBXO46 expression — UCEC

Explore this box plot interactively →