FBXO46

Across TCGA cell cohorts, FBXO46 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,011 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FBXO46-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Negative regulation of DNA-templated transcription, elongation, and Regulation of transcription initiation by RNA polymerase II. Each is linked with FBXO46 in more than 15 cancer types. Because this analysis shows association rather than direction, both FBXO46-to-partner and partner-to-FBXO46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by FBXO46-low versus FBXO46-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO46→partner) and Y-score (partner→FBXO46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of calcium ion export across plasma membrane →	+0.079	+0.825	.002	.001	3	16
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.164	+0.962	<.001	.001	3	16
PANCREAS	Regulation of transcription initiation by RNA polymerase II →	+0.063	+0.651	<.001	.001	3	15
STOMACH	Epigenetic regulation of gene expression →	+0.078	+0.991	<.001	.006	3	15
STOMACH	Negative regulation of chromosome condensation →	+0.198	+1.206	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription elongation by RNA polymerase II →	+0.071	+0.935	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,011 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by FBXO46 expression — OESOPHAGUS

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