FBXO46

Across TCGA cell cohorts, FBXO46 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXO46-associated genes across cancer lineages are OR10K1, SLC22A25, and LINGO4. Each is linked with FBXO46 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO46-to-partner and partner-to-FBXO46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K1 grouped by FBXO46-low versus FBXO46-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO46→partner) and Y-score (partner→FBXO46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10K1 →	+0.272	+2.556	.008	.007	3	2
LARGE_INTESTINE	SLC22A25 →	+0.011	+2.688	<.001	.008	3	2
LARGE_INTESTINE	LINGO4 →	+0.144	+3.869	<.001	.002	3	2
URINARY_TRACT	TMIGD3 →	+0.098	+4.584	<.001	.002	3	1
URINARY_TRACT	PRKACG →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	SMIM23 →	+0.010	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

OR10K1 by FBXO46 expression — BLOOD_Leukemia

Explore this box plot interactively →