FBXO43

Across TCGA pan-cancer cohorts, FBXO43 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FBXO43 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher FBXO43 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FBXO43 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, BLCA, and LUAD are the cancer types where FBXO43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	OS	Median	All	0.141	0.687	.003	18	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →
UCEC	DFS	Median	II,III,IV	0.933	0.434	.014	12	view →
BRCA	DFS	Median	All	0.112	0.526	.044	6	view →
ESCA	DFS	Median	II,III,IV	0.184	0.498	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FBXO43–THYM (OS)

Open the THYM breakdown →