FBXO41

Across TCGA patient cohorts, FBXO41 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO41-associated genes across cancer lineages are P-Cadherin, TFRC, and eEF2. Each is linked with FBXO41 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO41-to-partner and partner-to-FBXO41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by FBXO41-low versus FBXO41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO41→partner) and Y-score (partner→FBXO41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.107	-1.874	.032	.049	3	2
UCEC	TFRC →	+0.490	+2.584	.007	.010	3	2
UCEC	eEF2 →	+0.307	+2.459	.013	.018	3	1
UCEC	eIF4E →	+0.159	+3.183	.029	.009	3	1
UCEC	A-Raf_pS299 →	-0.146	-2.321	<.001	.005	3	1
UCEC	ERK2 →	+0.243	+2.807	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

P-Cadherin by FBXO41 expression — UCEC

Explore this box plot interactively →