FBXO4

Across TCGA patient cohorts, FBXO4 mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO4-associated genes across cancer lineages are NF1P12, MIR5189, and RN7SL447P. Each is linked with FBXO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO4-to-partner and partner-to-FBXO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P12 grouped by FBXO4-low versus FBXO4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO4→partner) and Y-score (partner→FBXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NF1P12 →	+0.317	+5.147	<.001	.003	3	2
BLCA	MIR5189 →	+0.348	+4.588	<.001	.008	3	2
UCEC	RN7SL447P →	+0.134	+2.281	.005	.007	3	2
UCEC	RNA5SP418 →	+0.812	+2.126	<.001	.007	3	2
HNSC	MTND4LP20 →	+0.208	+7.948	<.001	<.001	3	2
HNSC	RNA5SP73 →	+0.776	+5.015	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

NF1P12 by FBXO4 expression — BLCA

Explore this box plot interactively →