FBXO4

Across TCGA patient cohorts, FBXO4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO4-associated genes across cancer lineages are EGFR_pY1173, Ku80, and p62 Lck ligand. Each is linked with FBXO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO4-to-partner and partner-to-FBXO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by FBXO4-low versus FBXO4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO4→partner) and Y-score (partner→FBXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.081	+1.901	.030	.031	3	1
UCEC	Ku80 →	+0.256	+1.887	.020	.031	3	1
UCEC	p62 Lck ligand →	+0.369	+2.179	.014	.034	3	1
UCEC	Rab11 →	-0.145	-2.584	.032	.011	3	1
UCEC	Caspase-8 →	-0.253	-2.584	.030	.011	3	1
UCEC	p27_pT198 →	+0.101	+3.700	.042	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1173 by FBXO4 expression — UCEC

Explore this box plot interactively →