FBXO4

Across TCGA cell cohorts, FBXO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,531 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FBXO4-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, Nicotinate metabolic process, and Nicotinamide nucleotide biosynthetic process. Each is linked with FBXO4 in more than 8 cancer types. Because this analysis shows association rather than direction, both FBXO4-to-partner and partner-to-FBXO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by FBXO4-low versus FBXO4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO4→partner) and Y-score (partner→FBXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of DNA damage checkpoint →	+0.092	+1.018	<.001	<.001	3	9
CNS	Nicotinate metabolic process →	+0.078	+0.655	.001	.003	3	7
LARGE_INTESTINE	Nicotinamide nucleotide biosynthetic process →	+0.120	+0.686	<.001	.003	3	6
LARGE_INTESTINE	Pyridine nucleotide biosynthetic process →	+0.120	+0.686	<.001	.003	3	6
CNS	Positive regulation of telomere maintenance via telomerase →	-0.064	-0.632	<.001	.002	3	6
LUNG_SCLC	Protein localization to heterochromatin →	+0.101	+1.026	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,531 associations by consensus.

Regulation of DNA damage checkpoint by FBXO4 expression — OVARY

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