FBXO4

Across TCGA cell cohorts, FBXO4 mutation is significantly associated with the drug of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO4-associated genes across cancer lineages are GSK1904529A, AGI-6780, and Dacarbazine. Each is linked with FBXO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO4-to-partner and partner-to-FBXO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK1904529A grouped by FBXO4-low versus FBXO4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO4→partner) and Y-score (partner→FBXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK1904529A →	+0.352	+2.678	.026	.037	3	1
LARGE_INTESTINE	AGI-6780 →	+0.363	+2.868	.049	.022	3	1
LARGE_INTESTINE	Dacarbazine →	+0.269	+3.000	.042	.017	3	1
LARGE_INTESTINE	NSC-207895 →	+0.474	+3.008	.020	.016	3	1
LARGE_INTESTINE	PF-00299804 →	+0.586	+2.874	.007	.021	2	1
LARGE_INTESTINE	Torin 2 →	+0.684	+2.877	.006	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GSK1904529A by FBXO4 expression — LARGE_INTESTINE

Explore this box plot interactively →