FBXO38

Across TCGA pan-cancer cohorts, FBXO38 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FBXO38 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBXO38 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO38 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where FBXO38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.302	0.497	.008	40	view →
LUAD	OS	Median	All	0.912	0.748	.001	10	view →
LSCC	OS	Median	All	0.919	1.000	.008	10	view →
UCEC	OS	Quartile	All	1.000	0.892	.033	4	view →
GBM	DFS	Quartile	All	0.428	0.285	.017	2	view →
HNSC	DFS	Median	III,IV	0.721	0.852	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FBXO38–PDAC (DFS)

Open the PDAC breakdown →