FBXO38

Across TCGA pan-cancer cohorts, FBXO38 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FBXO38’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FBXO38 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXO38 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, KIRC, and LIHC are the cancer types where FBXO38 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO38 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−0.804	<.001	9	view →
KIRC	Female	All	+0.540	<.001	8	view →
LIHC	Female	All	+0.654	<.001	7	view →
HNSC	Female	III,IV	+0.635	.015	5	view →
THCA	Male	II,III,IV	−0.352	.011	5	view →
COAD	Male	All	+0.241	.011	5	view →
CHOL	All	All	+1.144	<.001	3	view →
UCEC	All	All	−0.469	.007	2	view →
ESCA	Male	All	+0.423	.031	2	view →
KICH	All	All	−0.435	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FBXO38–LUSC

Open the LUSC breakdown →